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User: Drkrishnasarmapathy
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Blob Industrial process for OXICONAZOLE Dr Krishnasarma P...

Created: 2012-07-24 11:38:44 | Last updated: 2013-06-21 09:49:15

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Industrial process for OXICONAZOLE Dr Krishnasarma PathyOxiconazole inhibits ergosterol biosynthesis, which is required forcytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochromeP450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in thecell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxiconazole hasalso been shown in inhibit DNA synthesis and suppress intracellular concentrations ofATP. Like other imidazole an...

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Blob Krishnasarma pathy, (2017) The influenza A virus sub...

Created: 2017-11-20 11:10:44

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The discovery of a new, biologic host-defense protein, “HDFx”, may provide a unique way to ameliorate and prevent the “cytokinestorms” and haemorrhages seen in severe influenza infections.The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent inpig populations worldwide. All scientific data point towards swine as the key host species for new human influenza pandemics, whichhave been suggested to evolve in pigs from viral genes of avian, human and porcine orig...

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Blob Krishnasarma pathy, (2017) The influenza A virus sub...

Created: 2017-11-20 11:10:20

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The discovery of a new, biologic host-defense protein, “HDFx”, may provide a unique way to ameliorate and prevent the “cytokinestorms” and haemorrhages seen in severe influenza infections.The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent inpig populations worldwide. All scientific data point towards swine as the key host species for new human influenza pandemics, whichhave been suggested to evolve in pigs from viral genes of avian, human and porcine orig...

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Blob The influenza A virus subtypes H1N1, H1N2 and H3N2 ,...

Created: 2017-11-16 12:21:14

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The influenza A virus subtypes H1N1, H1N2 and H3N2 ,HDFx: A NovelImmunomodulator and Potential Fighter Against Cytokine Storms inViral Flu Infections- Carica papaya Linn 

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Blob Oxcarbazepine by HPLC Method

Created: 2017-04-12 10:18:08

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

~Oxcarbazepine is in a class of drug called anticonvulsants. It inhibits unusual electrical activity in the brain. Oxcarbazepine may help control seizures, but it does not cure the disease. However, this medication is also used for treatment of epilepsy. Oxcarbazepine HPLC chromatography determination method was developed to quantify the quality of the synthesized drug. The developed method was then validated for the determination of Oxcarbazepine The separation was achieved in a octylsilyl s...

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Blob 5 Batch Analysis,Guidance to the manufacturer and th...

Created: 2016-09-10 09:21:16

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

~~The term ‘5 – batch analysis’ originates from the US EPA guidelines for testing of pesticides. The term is accepted now by most regulatory bodies like EEC, Indian registration authorities namely CIB & RC and other countries as well. There are no guidelines of OECD for this study. The study is essential to determine the composition of the product with respect to the active ingredient and its associated impurities.

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Blob SILDENAFIL CITRATE (Viagra) IN ITS POLYMORPHIC FORMS

Created: 2013-04-08 05:17:04

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

 AN IMPROVED PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE (Viagra) IN ITS POLYMORPHIC FORM The present invention provides an improved process for preparation of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H –pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulphonyl]-4methypiperazine citrate (Sildenafil Citrate) ofPolymorphic form I)

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Blob STUDY OF QUANTIFICATION OF IMPURITIES AND RELATED SU...

Created: 2012-08-13 16:46:39

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

    Bulk drug during its production process, after its scale up, it is necessary to analyse for the presence of any impurities or related substances in it. This is to ensure the impurities and related substances are within their limits as per ICH Guidelines. The impurities and related substances are defined as; Impurity: Any component present in the drug substance or drug product which is not the desired product, a product-related substance, or excipient including buffer com...

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Blob Process for the preparation of amorphous atorvastati...

Created: 2012-07-24 12:07:03

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Atorvastatin calcium is a drug compound that is used as a lipid-lowering agent, fortreating hypercholesterolemia. The compound has the chemical name[R-(R*,R*)]-2-(4-fluorophenyl)-3,ö-dihydroxy-5-(1-methylethyl)-3-phenyl-4-{(phenylamino)carbonyl}-1H-pyrolle-1-hepatonic acid, calcium salt (2:1) trihydrate. Pharmaceutical productscontaining crystalline atorvastatin calcium trihydrate are sold using the trademarkLIPITOR.

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Blob Novel polymorph of 5-cyanopthalide high purity inter...

Created: 2012-07-24 12:02:16

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The present invention relates to obtaining a new polymorph of 5-Cyanophthalide in highly pure form (99.5 to 99.99%), which is an intermediate used forthe synthesis of citalopram& escitalopram both of which are potent antidepressant drugs.Moreover this new polymorph of 5-cyanophthalide does not contain impurities liketerephthalic acid & diphthalide derivatives.        

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