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Blob Industrial process for OXICONAZOLE Dr Krishnasarma P...

Created: 2012-07-24 11:38:44 | Last updated: 2013-06-21 09:49:15

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Industrial process for OXICONAZOLE Dr Krishnasarma PathyOxiconazole inhibits ergosterol biosynthesis, which is required forcytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochromeP450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in thecell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxiconazole hasalso been shown in inhibit DNA synthesis and suppress intracellular concentrations ofATP. Like other imidazole an...

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Blob Chronic Hepatitis (Chc), Viral Polymerase Nucleotide...

Created: 2019-10-12 11:22:31

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Sofosbuvir is a viral polymerase nucleotide inhibitor that was approved in December2013 by the United States Food and Drug Administration (FDA), and in January 2014by the European Medicines Agency for the treatment of HCV infection [1]. The WHOGuidelines for the screening, care and treatment of persons with hepatitis C infectionrecommend sofosbuvir in combination with ribavirin in genotypes 1, 2, 3 and 4 HCVinfection, either with or without pegylated interferon (depending on the HCV genotype)...

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Blob Bempedoic Acid a Small Molecule Drug Process and Syn...

Created: 2019-07-23 07:04:13

Credits: User Drkrishnasarmapathy

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Low Density Lipoprotein Cholesterol AbstractBempedoic acid (ETC-1002), a small molecule drug, promotes low density lipoprotein (LDL) receptor mediated clearanceof LDL-cholesterol (LDL-C) by inhibition of adenosine triphosphate citrate lyase (ACL), a mechanism complementary to thoseof existing lipid-modifying therapies. Bempedoic acid is a pro-drug activated specifically within the liver where it inhibits ACL,a regulatory checkpoint within the cholesterol biosynthesis pathway. By inhibiti...

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Blob Crystallization and Polymorphism-Scalable Process fo...

Created: 2018-12-04 11:45:47

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Crystallization and Polymorphism-Scalable Process for Celecoxib and It’s Polymorph From-3

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Blob Citation: Krishnasarma P, MS Chakravarthy. Crystalli...

Created: 2018-12-04 11:43:44

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Citation: Krishnasarma P, MS Chakravarthy. Crystallization and Polymorphism-Scalable Process for Celecoxib and It’s Polymorph From-3(Non- Steroidal Anti-Inflammatory Drug (NSAID). LOJ Med Sci 2(2)-2018. LOJMS.MS.ID.000134. 125Review ArticleCrystallization and Polymorphism-Scalable Process forCelecoxib and It’s Polymorph From-3 (Non- SteroidalAnti-Inflammatory Drug (NSAID) 

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Blob Cefpodoxime Proxetil and its By-Products: A Comparat...

Created: 2018-08-31 07:40:48

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Cefpodoxime Proxetil and its By-Products: A Comparative Study as Per EP-7 Krishnasarma pathy*LOJ Med Sci 

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Blob Biomedical Journal of Scientific & Technical Research.

Created: 2018-08-31 06:24:53

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Considerations for Successful Scale-Up to Tox Batches and Phase-Api (Bulk Drug substance)[*]       Krishnasarma pathy* DOI : 10.26717/BJSTR.2018.08.001662Biomedical Journal of Scientific & Technical Research.

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Blob Biomedical Journal of Scientific & Technical Researc...

Created: 2018-08-31 06:23:50

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Considerations for Successful Scale-Up to Tox Batches and Phase-Api (Bulk Drug substance)[*]       Krishnasarma pathy* DOI : 10.26717/BJSTR.2018.08.001662Biomedical Journal of Scientific & Technical Research.

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Blob Case History-The Control of Impurities-A Critical Is...

Created: 2018-08-01 05:40:18

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Case History-The Control of Impurities-A CriticalIssue to The Active Pharmaceutical Ingredient 

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Blob Case History-The Control of Impurities-A Critical Is...

Created: 2018-08-01 05:35:55

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Case History-The Control of Impurities-A CriticalIssue to The Active Pharmaceutical Ingredient 

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