User: Henrry Mo

Name: Henrry Mo

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GGTase

Created: 2016-10-24 06:00:22

Credits: Henrry Mo

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Geranylgeranyltransferase type 1 or simply geranylgeranyltransferase is one of the three enzymes in the prenyltransferase group. In specific terms, Geranylgeranyltransferase (GGTase 1) adds a 20-carbon isoprenoid called a geranylgeranyl group to proteins bearing a CaaX motif:a four-amino acid sequence at the carboxyl terminal of a protein. Geranylgeranyltransferase inhibitors are being investigated as anti-cancer agents.

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