File Entry: Oxcarbazepine by HPLC Method

Created: 2017-04-12 10:18:08
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Version created on: 2017-04-12 10:18:07


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~Oxcarbazepine is in a class of drug called anticonvulsants. It inhibits unusual electrical activity in the brain. Oxcarbazepine may help control seizures, but it does not cure the disease. However, this medication is also used for treatment of epilepsy. Oxcarbazepine HPLC chromatography determination method was developed to quantify the quality of the synthesized drug. The developed method was then validated for the determination of Oxcarbazepine The separation was achieved in a octylsilyl silica gel C18 column (4.6 × 250 mm, 5 μm), using a mobile phase consist of 1.4 ml of H3PO4 and 1 ml of Triethyl amine buffer at (pH 6.5) and 25% Acetonitrile (ACN). The flow rate was 1.5 mL/min, injection volume 20 μL and detection at 215 nm. The drug was exposed to different degradation conditions such as acid hydrolysis, basic hydrolysis, hydrogen peroxide oxidation, heat and UV light. The degradation products were well separated from the main peak. The developed method was validated in respect to Specificity, Robustness, Linearity, Accuracy, Precision, according to FDA and ICH guidelines.


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