This workflow uses one or more services that are deprecated as of 31st December 2012 (over 11 years ago), and may no longer function. Show details...

Drug Re-Purposing Workflow

Created: 2011-03-25 20:06:13      Last updated: 2011-04-01 12:40:56

The drug repurposing workflow system screens at least 20 bacterial proteomes against this set of proteins that are already being treated against using established drugs. By screening the bacterial proteomes it will be possible to find proteins of highly similar structure to those that are existing drug protein targets and so this will infer that it is highly likely that the drugs can be used as antimicrobials against these proteins of highly similar structure. Proteomes that will be screened belong to Gram positive bacteria, with special focus on Staphylococcus aureus. We look at a variety of species and strains as the company advised. A mixture of screening targets could potentially identify targets for broad-spectrum antimicrobial development. The drug repurposing workflow shows where in the KEGG pathways the proteins are active and therefore where the action of the drug will be in the biochemical pathways of the bacteria. The workflow will update the Ondex database where new information on Gene Ontology annotations, functional annotation and literature references are available. All information about each unique protein is made available in an HTML document.

Information Preview

Information Run

Run this Workflow in the Taverna Workbench...

Option 1:

Copy and paste this link into File > 'Open workflow location...'
[ More InfoExpand ]

Information Workflow Components

Information Authors (0)
Information Titles (1)
Information Descriptions (1)
Information Dependencies (0)
Inputs (4)
Processors (37)
Beanshells (24)
Outputs (8)
Datalinks (60)
Coordinations (2)

Information Workflow Type

Taverna 2

Information Uploader

Information License

All versions of this Workflow are licensed under:

Information Version 6 (latest) (of 6)

View version:

Information Credits (2)


Information Attributions (0)



Information Tags (7)

Log in to add Tags

Information Shared with Groups (1)

Information Featured In Packs (0)


Log in to add to one of your Packs

Information Attributed By (0)



Information Favourited By (0)

No one

Information Statistics


Citations (0)


Version History

In chronological order:

Reviews Reviews (0)

No reviews yet

Be the first to review!

Comments Comments (0)

No comments yet

Log in to make a comment

Workflow Other workflows that use similar services (101)

Only the first 2 workflows that use similar services are shown. View all workflows that use these services.

Workflow Vaccine Targets Workflow (3)

Comparison of the genome of Bacillus anthracis to closely related strains will allow the discovery of proteins which may be involved in pathogenicity. Based on the biochemical pathways where the protein interacts, vaccines can be designed for these unique proteins. By gaining insight into the biochemical pathways that the unique proteins are involved in, the proteins can also be assessed for potential quality as vaccines. The key components of the vaccine finding system are the following: T...

Created: 2011-03-30 | Last updated: 2011-04-01

Credits: User Morgan Taschuk Network-member A Team

Workflow KEGG Pathways and Additional Information f... (2)

Takes in a tab-delimited BLAST file and finds additional information about the target proteins from KEGG, Gene Ontology, Interpro and PubMed.

Created: 2011-03-29 | Last updated: 2011-03-30

Credits: User Morgan Taschuk

Attributions: Workflow extract_uniprot_embl_gi.xml