Created: 2011-03-28 11:34:18      Last updated: 2011-08-09 22:38:12

The ADR substantiation (ADR-S) workflow seeks to establish a connection between the clinical event and the drug through (i) proteins being targeted by the drug (or by its metabolites) and are associated with the clinical event and (ii) through biological pathways. 

In the first connecting path, the link between the drug and the event is established through the set of proteins in common between the Drug-Target-Profile and the Event-Protein-Profile. In the second path, the link is established through a set of proteins that are part of the same biological pathway. For example, consider a protein A targeted by the drug and a protein B associated with the clinical event, and both proteins A and B are part of the same biological pathway C. Then, the drug and the event are connected through biological pathway C.

For more details see "Bauer-Mehren et al., Automatic filtering and substantiation of drug safety signals."




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