Epitope-based Vaccine Design Workflow using ImmunoNodes
Population-based vaccine design workflow in KNIME. AlleleFrequency is used to specify the geographical region or population of interest and returns a tab-separated list of HLA alleles with their corresponding occurrence probability within the selected population. This file, together with a FASTA file containing protein sequences, or a file containing peptides is used as input to EpitopePrediction, which generates a file containing the predicted binding affinities of the (generated) peptides and the selected HLA alleles. This file, in turn, is used as input to EpitopeSelection, which selects a user-defined number of epitopes out of the candidate pool and writes these together with other statistics into an output file.?
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