Global Shape Analysis Workflow

Created: 2011-04-06 00:18:59      Last updated: 2011-04-06 00:19:03

This workflow takes raw un-skull-stripped volumes in multiple groups/populations, or a Study-Design, and generates a scene file containing the models of the ROIs where the groups are different. It also reports the global 56 regional p-values.

Problem addressed by this workflow


Identifying the group differences between 2 populations in the global shapes of 56 cortical and sub-cortical ROIs. This workflow also generates DX models of all 56 ROIs which can be viewed as a scene in ShapeViewer.


Detailed Workflow Usage & Specifications

  • Input: Any volumetric file format can be used for the raw unskull-stripped imput images (e.g., DICOM, DIrectories, Analyze, MNC, Nifti, etc.)
  • Pre-processing
    • Image conversion to Analyze
    • Converting to 8-bit
    • Intensity Inhomogeneity correction
    • Skull-stripping
    • Affine Registration
  • Auto Volume Parsing
  • 56 Shape Modeling and Refinement
  • Between-Group Statistical Analyses
    • Compute various global shape measures for 56 ROIs (average mean curvature, surface area, volume, shape index, curvedness, fractal dimension)
    • Shape Measure Tabulation
    • Group comparisons per ROI
    • Compute p-values
  • Generate and display scene file


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LONI Pipeline

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