myExperiment

Uploader

Drkrish...

View

Download

Industrial process for OXICONAZOLE Dr Krishnasarma P...

Created: 2012-07-24 11:38:44 | Last updated: 2013-06-21 09:49:15

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Industrial process for OXICONAZOLE Dr Krishnasarma PathyOxiconazole inhibits ergosterol biosynthesis, which is required forcytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochromeP450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in thecell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxiconazole hasalso been shown in inhibit DNA synthesis and suppress intracellular concentrations ofATP. Like other imidazole an...

File type: Adobe PDF

Comments: 0 | Viewed: 74 times | Downloaded: 119 times

Tags:

5-cyanophthalide; high purity; terephthalic acid & diphthalide derivatives; alkyl carbomate

Uploader

Drkrish...

View

Download

Antiviral Drugs in the battle against COVID-19 & Min...

Created: 2022-02-02 07:17:26

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Patent Evaluation of Antiviral Drugs in the battle against COVID-19 &Minimization of Risks Associated with Occurrence of Dangerousviral mutations During Treatment with Antiviral Mutagenic Agents

File type: Adobe PDF

Comments: 0 | Viewed: 49 times | Downloaded: 9 times

Tags:

Uploader

Drkrish...

View

Download

International Journal of Research Studies in Medical...

Created: 2020-08-21 11:22:57

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Abstract – Hydroquinone as a volatile aromatic hydrocarbon; There is a huge confusion in the public, as well as among politicians and even some scientists, about those two molecules. That confusion ultimately led to people accidently overdosing. Both molecules can be classified as 4-aminoquinolines, and both have anti-plasmodial activities, but they remain two different molecules with some different metabolites. Chloroquine has been widely used since the 1950s for prophylactic and ...

File type: Adobe PDF

Comments: 0 | Viewed: 58 times | Downloaded: 11 times

Tags:

Uploader

Drkrish...

View

Download

Antiviral nucleosides- Flu Viruses- QUINOLINES-COV...

Created: 2020-08-21 10:58:20 | Last updated: 2020-08-21 10:58:52

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Antiviral nucleosides- Flu Viruses- QUINOLINES-COVID-19 Hydroquinone as a volatile aromatic hydrocarbon; There is a huge confusion in the public, as well as among politicians and even some scientists, about those two molecules. That confusion ultimately led to people accidently overdosing. Both molecules can be classified as 4-aminoquinolines, and both have anti-plasmodial activities, but they...

File type: Adobe PDF

Comments: 0 | Viewed: 44 times | Downloaded: 6 times

This File has no tags!

Uploader

Drkrish...

View

Download

HCV NS3/4A 3 Protease Inhibitors: Simeprevir, Proces...

Created: 2020-02-19 06:12:03

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

In polymerase and protease drug targets and drug development, which has resulted in a strong infectious disease R&D portfolio,”and has given the company its key pipeline asset, simeprevir (TMC435), a novel protease inhibitor in Phase III clinicaldevelopment for hepatitis C that is being developed in collaboration with Janssen Pharmaceuticals. Currently, hepatitis C virus(HCV) infection is considered a serious health-care problem all over the world. A good number of direct-acting ant...

File type: Adobe PDF

Comments: 0 | Viewed: 15 times | Downloaded: 4 times

This File has no tags!

Uploader

Drkrish...

View

Download

Chronic Hepatitis (Chc), Viral Polymerase Nucleotide...

Created: 2019-10-12 11:22:31

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Sofosbuvir is a viral polymerase nucleotide inhibitor that was approved in December2013 by the United States Food and Drug Administration (FDA), and in January 2014by the European Medicines Agency for the treatment of HCV infection [1]. The WHOGuidelines for the screening, care and treatment of persons with hepatitis C infectionrecommend sofosbuvir in combination with ribavirin in genotypes 1, 2, 3 and 4 HCVinfection, either with or without pegylated interferon (depending on the HCV genotype)...

File type: Adobe PDF

Comments: 0 | Viewed: 15 times | Downloaded: 4 times

This File has no tags!

Uploader

Drkrish...

View

Download

Bempedoic Acid a Small Molecule Drug Process and Syn...

Created: 2019-07-23 07:04:13

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Low Density Lipoprotein Cholesterol AbstractBempedoic acid (ETC-1002), a small molecule drug, promotes low density lipoprotein (LDL) receptor mediated clearanceof LDL-cholesterol (LDL-C) by inhibition of adenosine triphosphate citrate lyase (ACL), a mechanism complementary to thoseof existing lipid-modifying therapies. Bempedoic acid is a pro-drug activated specifically within the liver where it inhibits ACL,a regulatory checkpoint within the cholesterol biosynthesis pathway. By inhibiti...

File type: Adobe PDF

Comments: 0 | Viewed: 24 times | Downloaded: 8 times

This File has no tags!

Uploader

Drkrish...

View

Download

Crystallization and Polymorphism-Scalable Process fo...

Created: 2018-12-04 11:45:47

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Crystallization and Polymorphism-Scalable Process for Celecoxib and It’s Polymorph From-3

File type: Adobe PDF

Comments: 0 | Viewed: 15 times | Downloaded: 5 times

This File has no tags!

Uploader

Drkrish...

View

Download

Citation: Krishnasarma P, MS Chakravarthy. Crystalli...

Created: 2018-12-04 11:43:44

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Citation: Krishnasarma P, MS Chakravarthy. Crystallization and Polymorphism-Scalable Process for Celecoxib and It’s Polymorph From-3(Non- Steroidal Anti-Inflammatory Drug (NSAID). LOJ Med Sci 2(2)-2018. LOJMS.MS.ID.000134. 125Review ArticleCrystallization and Polymorphism-Scalable Process forCelecoxib and It’s Polymorph From-3 (Non- SteroidalAnti-Inflammatory Drug (NSAID)

File type: Adobe PDF

Comments: 0 | Viewed: 30 times | Downloaded: 5 times

This File has no tags!

Uploader

Drkrish...

View

Download

Cefpodoxime Proxetil and its By-Products: A Comparat...

Created: 2018-08-31 07:40:48

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Cefpodoxime Proxetil and its By-Products: A Comparative Study as Per EP-7 Krishnasarma pathy*LOJ Med Sci

File type: Adobe PDF

Comments: 0 | Viewed: 6 times | Downloaded: 4 times

Tags:

cefpodoxime proxetil and its by-products: a comparative study as per ep-7 krishnasarma pathy* loj med sci

Uploader

Drkrish...

View

Download

Biomedical Journal of Scientific & Technical Research.

Created: 2018-08-31 06:24:53

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Considerations for Successful Scale-Up to Tox Batches and Phase-Api (Bulk Drug substance)[*] Krishnasarma pathy* DOI : 10.26717/BJSTR.2018.08.001662Biomedical Journal of Scientific & Technical Research.

File type: Adobe PDF

Comments: 0 | Viewed: 10 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

Biomedical Journal of Scientific & Technical Researc...

Created: 2018-08-31 06:23:50

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Considerations for Successful Scale-Up to Tox Batches and Phase-Api (Bulk Drug substance)[*] Krishnasarma pathy* DOI : 10.26717/BJSTR.2018.08.001662Biomedical Journal of Scientific & Technical Research.

File type: Adobe PDF

Comments: 0 | Viewed: 6 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

Case History-The Control of Impurities-A Critical Is...

Created: 2018-08-01 05:40:18

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Case History-The Control of Impurities-A CriticalIssue to The Active Pharmaceutical Ingredient

File type: Adobe PDF

Comments: 0 | Viewed: 10 times | Downloaded: 6 times

Tags:

Uploader

Drkrish...

View

Download

Case History-The Control of Impurities-A Critical Is...

Created: 2018-08-01 05:35:55

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Case History-The Control of Impurities-A CriticalIssue to The Active Pharmaceutical Ingredient

File type: Adobe PDF

Comments: 0 | Viewed: 4 times | Downloaded: 2 times

Tags:

Uploader

Drkrish...

View

Download

Herald Scholarly Open Access Pathy K (2018) Entecavi...

Created: 2018-07-28 07:03:39

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Herald Scholarly Open Access krishnasarma Pathy K (2018) Entecavir Patent Evaluation & Genotoxicity.pdf

File type: Adobe PDF

Comments: 0 | Viewed: 5 times | Downloaded: 5 times

Tags:

Uploader

Drkrish...

View

Download

Herald Scholarly Open Accesskrishnasarma Pathy K (20...

Created: 2018-07-28 07:01:30 | Last updated: 2018-07-28 07:01:52

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Herald Scholarly Open Accesskrishnasarma Pathy K (2018) Entecavir Patent Evaluation & Genotoxicity.

File type: Adobe PDF

Comments: 0 | Viewed: 7 times | Downloaded: 3 times

Tags:

Uploader

Drkrish...

View

Download

Krishnasarma Pathy (2018) Process for Preparation of...

Created: 2018-07-14 06:13:35

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Krishnasarma Pathy (2018) Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets. SF J Chem Res 2:1.

File type: Adobe PDF

Comments: 0 | Viewed: 4 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

Method for Preparation of Vitamin C and Method for D...

Created: 2018-07-14 06:12:11

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Procedure for calcium ascorbate (VITAMIN-C) includes such technological steps as reaction of ascorbic acidon calcium carbonate in water in recent years; the determination of vitamin C has become an important subject in the fieldof biochemistry and commercial foods. This is because vitamin C plays an important role in maintaining human health.Due to the importance of vitamin C in human beings, the quantitative analysis of vitamin C has gained a significantincrease in several areas of analytica...

File type: Adobe PDF

Comments: 0 | Viewed: 3 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

Entecavir Patent Evaluation, Method for Diastereomer...

Created: 2018-06-29 10:47:08 | Last updated: 2018-06-29 10:48:15

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Entecavir Patent Evaluation, Method for Diastereomeric ImpuritiesEntecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV), which inhibits reverse transcription, The initial patent on entecavir expired in South Africa in 2011 ZA 1991/07894. Current status available on: http://patentsearch.cipc.co.za/, which should have permitted lower-cost generic competitors to enter...

File type: Adobe PDF

Comments: 0 | Viewed: 6 times | Downloaded: 4 times

This File has no tags!

Uploader

Drkrish...

View

Download

Organic and Medicinal Chemistry International Journa...

Created: 2018-06-29 10:43:43

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Organic and Medicinal Chemistry International Journal:Entecavir Patent Evaluation, Method for Diastereomeric ImpuritiesEntecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV), which inhibits reverse transcription, The initial patent on entecavir expired in South Africa in 2011 ZA 1991/07894. Current status available on: http://patentsearch.cipc.co.za/, which should ...

File type: Adobe PDF

Comments: 0 | Viewed: 6 times | Downloaded: 3 times

This File has no tags!

Uploader

Drkrish...

View

Download

krishnasarmapathy-Entecavir Patent Evaluation, Molec...

Created: 2018-06-21 05:38:08

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV), which inhibits reverse transcription, Hepatitis B virus (HBV) is highly endemic in South Africa and across sub-Saharan Africa, where around 8% of people are chronically infected, and rates of HBV-related liver cancer are some of the highest in the world. Globally, viral hepatitis causes approximately 1.3 milli...

File type: Adobe PDF

Comments: 0 | Viewed: 6 times | Downloaded: 2 times

Tags:

Uploader

Drkrish...

View

Download

Entecavir Patent Evaluation, Molecular Modelling Stu...

Created: 2018-06-21 05:36:07

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV), which inhibits reverse transcription, Hepatitis B virus (HBV) is highly endemic in South Africa and across sub-Saharan Africa, where around 8% of people are chronically infected, and rates of HBV-related liver cancer are some of the highest in the world. Globally, viral hepatitis causes approximately 1.3 milli...

File type: Adobe PDF

Comments: 0 | Viewed: 7 times | Downloaded: 5 times

This File has no tags!

Uploader

Drkrish...

View

Download

Process for Preparation of Vitamin C and Method for ...

Created: 2018-06-19 06:44:55

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets

File type: Adobe PDF

Comments: 0 | Viewed: 5 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

Process for Preparation of Vitamin C and Method for ...

Created: 2018-06-19 06:43:19 | Last updated: 2018-06-19 06:43:37

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets

File type: Adobe PDF

Comments: 0 | Viewed: 6 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

SCHOLARLY JOURNAL OF FOOD AND NUTRITION-Route Evalua...

Created: 2018-06-04 05:32:46 | Last updated: 2018-06-04 05:34:44

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

This is out line work on the process development for the synthesis of buprenorphine, naltrexone, naloxone, and nalbuphine from naturally occurring opiates such as Thebaine, also known as codeine methyl enol ether, and oripavine. Several new methods for N-demethylation of morphinans have been developed during the pursuit of this research. The article traces the evolution of various approaches and provides a comparison for overall efficiency. A reverse phase high performance liquid chromatograp...

File type: Adobe PDF

Comments: 0 | Viewed: 9 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

Route Evaluation and Analytical HPLC Method Developm...

Created: 2018-06-04 05:30:06 | Last updated: 2018-06-04 05:30:26

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

This is out line work on the process development for the synthesis of buprenorphine, naltrexone, naloxone, and nalbuphine from naturally occurring opiates such as Thebaine, also known as codeine methyl enol ether, and oripavine. Several new methods for N-demethylation of morphinans have been developed during the pursuit of this research. The article traces the evolution of various approaches and provides a comparison for overall efficiency. A reverse phase high performance liquid chromatograp...

File type: Adobe PDF

Comments: 0 | Viewed: 8 times | Downloaded: 3 times

This File has no tags!

Uploader

Drkrish...

View

Download

process development of antiviral agents : Amantadin...

Created: 2018-05-05 07:09:19

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Recent advances in process development of antiviral agents targeting the influenza virus: Amantadine-Remantadine-derived pharmaceutical agents"

File type: Adobe PDF

Comments: 0 | Viewed: 9 times | Downloaded: 4 times

This File has no tags!

Uploader

Drkrish...

View

Download

Recent advances in process development of antiviral ...

Created: 2018-05-05 07:08:14

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Recent advances in process development of antiviral agents targeting the influenza virus: Amantadine-Remantadine-derived pharmaceutical agents"

File type: Adobe PDF

Comments: 0 | Viewed: 8 times | Downloaded: 4 times

This File has no tags!

Uploader

Drkrish...

View

Download

IJMSCI Recent advances in process development of ant...

Created: 2018-05-05 07:07:31

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Recent advances in process development of antiviral agents targeting the influenza virus: Amantadine-Remantadine-derived pharmaceutical agents"

File type: Adobe PDF

Comments: 0 | Viewed: 8 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

Bigunidine Metformin Pharmacologically Efficacious T...

Created: 2018-03-23 07:50:58

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Metformin usage may be considered for people with type 2 diabetes to help them control their blood sugar levels a secondary sideeffect may be weight loss, which leads some to believe it may be a viable medication to use for weight loss. However, researchers arestill not clear on whether or not metformin has an actual impact on weight, or if weight loss is due to lifestyle changes in people withtype 2 diabetes. Metformin (Glucophage, Glumetza, Fortamet) is typically prescribed to counteract th...

File type: PNG image

Comments: 0 | Viewed: 16 times | Downloaded: 6 times

This File has no tags!

Uploader

Drkrish...

View

Download

Bigunidine Metformin Pharmacologically Efficacious T...

Created: 2018-03-23 07:49:08

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Metformin usage may be considered for people with type 2 diabetes to help them control their blood sugar levels a secondary sideeffect may be weight loss, which leads some to believe it may be a viable medication to use for weight loss. However, researchers arestill not clear on whether or not metformin has an actual impact on weight, or if weight loss is due to lifestyle changes in people withtype 2 diabetes. Metformin (Glucophage, Glumetza, Fortamet) is typically prescribed to counteract th...

File type: XML

Comments: 0 | Viewed: 20 times | Downloaded: 6 times

This File has no tags!

Uploader

Drkrish...

View

Download

Synthesis of Sildenafil Citrate Validated HPLC Metho...

Created: 2018-03-23 07:47:52

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The present study describes analytical method of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H–pyrazolo[4,3-d]pyrimidin-5-yl)-4- ethoxyphenyl]sulphonyl]-4methypiperazine citrate (sildenafil Citrate). The following specification particularly describes and ascertains the nature of this invention, and the manner in which it is to be performed. Sildenafil is an oral drug used primarily to treat male sexual function problems (impotence or erectile dysfunction) since becoming available in 199...

File type: Adobe PDF

Comments: 0 | Viewed: 9 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

Synthesis of Sildenafil Citrate Validated HPLC Metho...

Created: 2018-03-23 07:46:48

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The present study describes analytical method of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H–pyrazolo[4,3-d]pyrimidin-5-yl)-4- ethoxyphenyl]sulphonyl]-4methypiperazine citrate (sildenafil Citrate). The following specification particularly describes and ascertains the nature of this invention, and the manner in which it is to be performed. Sildenafil is an oral drug used primarily to treat male sexual function problems (impotence or erectile dysfunction) since becoming available in 199...

File type: XML

Comments: 0 | Viewed: 16 times | Downloaded: 4 times

This File has no tags!

Uploader

Drkrish...

View

Download

Antihistamine Drugs Possess some Antiacetylcholine P...

Created: 2018-03-10 06:27:28

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Antihistamine Drugs Possess someAntiacetylcholine Properties

File type: Adobe PDF

Comments: 0 | Viewed: 9 times | Downloaded: 3 times

This File has no tags!

Uploader

Drkrish...

View

Download

Epidemic Flu Viruses & the influenza a virus

Created: 2018-03-10 06:26:15

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Epidemic Flu Viruses & the influenza a virus

File type: JPEG image

Comments: 0 | Viewed: 10 times | Downloaded: 4 times

This File has no tags!

Uploader

Drkrish...

View

Download

Nutri Food Sci Int J 5(5): NFSIJ.MS.ID.555674 (2018)...

Created: 2018-03-10 06:24:50

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Nutri Food Sci Int J 5(5): NFSIJ.MS.ID.555674 (2018) 001

File type: JPEG image

Comments: 0 | Viewed: 9 times | Downloaded: 4 times

This File has no tags!

Uploader

Drkrish...

View

Download

Krishnasarma Pathy* DOI: 10.19080/OAJT.2018.02.55559...

Created: 2018-03-09 08:06:21

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Epidemic Flu Viruses & the influenza a virus subtypes H1N1, H1N2 and H3N2, HDFxKrishnasarma Pathy*Head of QC/QA, IPL Research Centre, IndiaSubmission: October 31, 2017; Published: March 07, 2018*Corresponding author: Krishnasarma Pathy, Head of QC/QA, IPL Research Centre, India, Tel: 9919188895,Email:Open Acc J of Toxicol. 2018; 2(4): OAJT.MS.ID.555593 (2018)001Mini ReviewThe history of flu viruses teaches that the influence has origin from animal’s birds, generically aquatic, and t...

File type: Adobe PDF

Comments: 0 | Viewed: 5 times | Downloaded: 4 times

This File has no tags!

Uploader

Drkrish...

View

Download

Krishnasarma Pathy*Flu Viruses Open Acc J of Toxicol...

Created: 2018-03-09 08:04:06

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Krishnasarma Pathy*Head of QC/QA, IPL Research Centre, IndiaSubmission: October 24, 2017; Published: March 07, 2018*Corresponding author: Krishnasarma Pathy, Head of QC/QA, IPL Research Centre, India, Tel: 9919188895Human H1N1 pandemic developed from the originally localized Mexican source early in the spring 2009. For the emergency created by the epidemic of influence of the pigs in Mexico it was correct not to create alarmism being victims of bad information. Cytokine storm should be mentio...

File type: Adobe PDF

Comments: 0 | Viewed: 4 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

Abstract Human H1N1 pandemic developed from the orig...

Created: 2018-03-08 10:54:10

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

For the emergency created by the epidemic of influence of the pigs in Mexico it was correct not to create alarmisms being victims of a bad information. The possibility that the virus arrives in other parts of the world is real as for all the types of influence virus. In order that a strain has a wide distribution, its antigenic characteristics must ensure that it escapes the neutralization of antibodies of the host and of the surrounding population. The discovery of a new, biologic Host-Defen...

File type: Adobe PDF

Comments: 0 | Viewed: 6 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

FLUVIRUSES

Created: 2018-03-08 10:51:51 | Last updated: 2018-03-08 10:52:22

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

AbstractHuman H1N1 pandemic developed from the originally localized Mexican source early in the spring 2009. For the emergency created by the epidemic of influence of the pigs in Mexico it was correct not to create alarmism being victims of bad information. Cytokine storm should be mentioned as one of the key pathogenic events contributing to the overall mortality in substantial portion of patients. If active immunization is assumed to be preventive measure of proven efficacy, clinicians are ...

File type: Adobe PDF

Comments: 0 | Viewed: 4 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

http://scifed.com/fulltext/the-influenza-a-virus-sub...

Created: 2017-12-28 05:55:47 | Last updated: 2017-12-28 05:55:56

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

http://scifed.com/fulltext/the-influenza-a-virus-subtypes-h1n1-h1n2-and-h3n2-hdfx-a-novel-immunomodulatorand-potential-fighter-against-cytokine-storms-in-viral-flu-infections-carica-papaya-linn/21844#one

File type: Adobe PDF

Comments: 0 | Viewed: 6 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

http://scifed.com/fulltext/the-influenza-a-virus-sub...

Created: 2017-12-28 05:54:34

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

http://scifed.com/fulltext/the-influenza-a-virus-subtypes-h1n1-h1n2-and-h3n2-hdfx-a-novel-immunomodulatorand-potential-fighter-against-cytokine-storms-in-viral-flu-infections-carica-papaya-linn/21844#one

File type: Adobe PDF

Comments: 0 | Viewed: 6 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

Krishnasarma pathy, (2017) The influenza A virus sub...

Created: 2017-11-20 11:10:44

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The discovery of a new, biologic host-defense protein, “HDFx”, may provide a unique way to ameliorate and prevent the “cytokinestorms” and haemorrhages seen in severe influenza infections.The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent inpig populations worldwide. All scientific data point towards swine as the key host species for new human influenza pandemics, whichhave been suggested to evolve in pigs from viral genes of avian, human and porcine orig...

File type: Adobe PDF

Comments: 0 | Viewed: 4 times | Downloaded: 3 times

This File has no tags!

Uploader

Drkrish...

View

Download

Krishnasarma pathy, (2017) The influenza A virus sub...

Created: 2017-11-20 11:10:20

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The discovery of a new, biologic host-defense protein, “HDFx”, may provide a unique way to ameliorate and prevent the “cytokinestorms” and haemorrhages seen in severe influenza infections.The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent inpig populations worldwide. All scientific data point towards swine as the key host species for new human influenza pandemics, whichhave been suggested to evolve in pigs from viral genes of avian, human and porcine orig...

File type: Adobe PDF

Comments: 0 | Viewed: 5 times | Downloaded: 2 times

This File has no tags!

Uploader

Drkrish...

View

Download

The influenza A virus subtypes H1N1, H1N2 and H3N2 ,...

Created: 2017-11-16 12:21:14

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The influenza A virus subtypes H1N1, H1N2 and H3N2 ,HDFx: A NovelImmunomodulator and Potential Fighter Against Cytokine Storms inViral Flu Infections- Carica papaya Linn

File type: Adobe PDF

Comments: 0 | Viewed: 11 times | Downloaded: 3 times

Tags:

Uploader

Drkrish...

View

Download

Oxcarbazepine by HPLC Method

Created: 2017-04-12 10:18:08

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

~Oxcarbazepine is in a class of drug called anticonvulsants. It inhibits unusual electrical activity in the brain. Oxcarbazepine may help control seizures, but it does not cure the disease. However, this medication is also used for treatment of epilepsy. Oxcarbazepine HPLC chromatography determination method was developed to quantify the quality of the synthesized drug. The developed method was then validated for the determination of Oxcarbazepine The separation was achieved in a octylsilyl s...

File type: Adobe PDF

Comments: 0 | Viewed: 32 times | Downloaded: 5 times

This File has no tags!

Uploader

Drkrish...

View

Download

5 Batch Analysis,Guidance to the manufacturer and th...

Created: 2016-09-10 09:21:16

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

~~The term ‘5 – batch analysis’ originates from the US EPA guidelines for testing of pesticides. The term is accepted now by most regulatory bodies like EEC, Indian registration authorities namely CIB & RC and other countries as well. There are no guidelines of OECD for this study. The study is essential to determine the composition of the product with respect to the active ingredient and its associated impurities.

File type: Adobe PDF

Comments: 0 | Viewed: 7 times | Downloaded: 8 times

This File has no tags!

Uploader

Drkrish...

View

Download

SILDENAFIL CITRATE (Viagra) IN ITS POLYMORPHIC FORMS

Created: 2013-04-08 05:17:04

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

AN IMPROVED PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE (Viagra) IN ITS POLYMORPHIC FORM The present invention provides an improved process for preparation of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H –pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulphonyl]-4methypiperazine citrate (Sildenafil Citrate) ofPolymorphic form I)

File type: Adobe PDF

Comments: 0 | Viewed: 215 times | Downloaded: 897 times

Tags:

Uploader

Drkrish...

View

Download

STUDY OF QUANTIFICATION OF IMPURITIES AND RELATED SU...

Created: 2012-08-13 16:46:39

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Bulk drug during its production process, after its scale up, it is necessary to analyse for the presence of any impurities or related substances in it. This is to ensure the impurities and related substances are within their limits as per ICH Guidelines. The impurities and related substances are defined as; Impurity: Any component present in the drug substance or drug product which is not the desired product, a product-related substance, or excipient including buffer com...

File type: Adobe PDF

Comments: 0 | Viewed: 186 times | Downloaded: 555 times

This File has no tags!

Uploader

Drkrish...

View

Download

Process for the preparation of amorphous atorvastati...

Created: 2012-07-24 12:07:03

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Atorvastatin calcium is a drug compound that is used as a lipid-lowering agent, fortreating hypercholesterolemia. The compound has the chemical name[R-(R*,R*)]-2-(4-fluorophenyl)-3,ö-dihydroxy-5-(1-methylethyl)-3-phenyl-4-{(phenylamino)carbonyl}-1H-pyrolle-1-hepatonic acid, calcium salt (2:1) trihydrate. Pharmaceutical productscontaining crystalline atorvastatin calcium trihydrate are sold using the trademarkLIPITOR.

File type: Adobe PDF

Comments: 0 | Viewed: 49 times | Downloaded: 112 times

This File has no tags!

Drkrishnasarmapathy's Files