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Industrial process for OXICONAZOLE Dr Krishnasarma P...
Created: 2012-07-24 11:38:44 | Last updated: 2013-06-21 09:49:15
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Drkrishnasarmapathy
License: Creative Commons Attribution-Share Alike 3.0 Unported License
Industrial process for OXICONAZOLE Dr Krishnasarma PathyOxiconazole inhibits ergosterol biosynthesis, which is required forcytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochromeP450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in thecell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxiconazole hasalso been shown in inhibit DNA synthesis and suppress intracellular concentrations ofATP. Like other imidazole an...
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