User: Jason burkhead
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Name: Jason burkhead Joined: Wednesday 01 May 2013 21:54:07 (UTC) Last seen: Tuesday 06 May 2014 22:00:15 (UTC) Email (public): jlburkhead [at] uaa.alaska.edu Website: http://www.uaa.alaska.edu/biology/facultyandstaff/burkhead.cfm Location: Anchorage, United States |
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My research studies molecular mechanisms of copper homeostasis. Copper is an essential micronutrient and redox active metal. Cellular and organismal levels of copper must be tightly maintained and correctly targeted to avoid both deficiency and toxicity. My lab incorporates biochemistry and molecular biology, cell biology, and rodent models to gain mechanistic data on copper metabolism and its roles in health and disease. One key project investigates mechanisms and roles of the signal integrator Copper Metabolism Murr1 Domain 1 (COMMD1) protein in hepatocellular copper export, including interaction of the protein with signaling lipids. Work with rodent models takes data-driven approaches to study of copper toxicity in a Wilson’s Disease model and copper deficiency and its role in chronic liver disease. New studies are translating information from animal studies to work directly in human liver disease.
Other contact details:
Not specifiedInterests:
copper metabolism, liver disease, data-driven biology, protein structure-function
Field/Industry: Biological Science
Occupation/Role(s): Faculty
Organisation(s):
ASBMBMy research studies molecular mechanisms of copper homeostasis. Copper is an essential micronutrient and redox active metal. Cellular and organismal levels of copper must be tightly maintained and correctly targeted to avoid both deficiency and toxicity. My lab incorporates biochemistry and molecular biology, cell biology, and rodent models to gain mechanistic data on copper metabolism and its roles in health and disease. One key project investigates mechanisms and roles of the signal integrator Copper Metabolism Murr1 Domain 1 (COMMD1) protein in hepatocellular copper export, including interaction of the protein with signaling lipids. Work with rodent models takes a systems approach to study of copper toxicity in a Wilson’s Disease model and copper deficiency and its role in chronic liver disease.
