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User: Drkrishnasarmapathy Licence: by-sa
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Blob Industrial process for OXICONAZOLE Dr Krishnasarma P...

Created: 2012-07-24 11:38:44 | Last updated: 2013-06-21 09:49:15

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Industrial process for OXICONAZOLE Dr Krishnasarma PathyOxiconazole inhibits ergosterol biosynthesis, which is required forcytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochromeP450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in thecell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxiconazole hasalso been shown in inhibit DNA synthesis and suppress intracellular concentrations ofATP. Like other imidazole an...

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Blob International Journal of Research Studies in Medical...

Created: 2020-08-21 11:22:57

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Abstract – Hydroquinone as a volatile aromatic hydrocarbon; There is a huge confusion in the public, as well as among politicians and even some scientists, about those two molecules. That confusion ultimately led to people accidently overdosing. Both molecules can be classified as 4-aminoquinolines, and both have anti-plasmodial activities, but they remain two different molecules with some different metabolites. Chloroquine has been widely used since the 1950s for prophylactic and ...

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Blob Antiviral nucleosides- Flu Viruses- QUINOLINES-COV...

Created: 2020-08-21 10:58:20 | Last updated: 2020-08-21 10:58:52

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Antiviral nucleosides-  Flu Viruses-                QUINOLINES-COVID-19 Hydroquinone as a volatile aromatic hydrocarbon; There is a huge confusion in the public, as well as among politicians and even some scientists, about those two molecules. That confusion ultimately led to people accidently overdosing. Both molecules can be classified as 4-aminoquinolines, and both have anti-plasmodial activities, but they...

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Blob HCV NS3/4A 3 Protease Inhibitors: Simeprevir, Proces...

Created: 2020-02-19 06:12:03

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

In polymerase and protease drug targets and drug development, which has resulted in a strong infectious disease R&D portfolio,”and has given the company its key pipeline asset, simeprevir (TMC435), a novel protease inhibitor in Phase III clinicaldevelopment for hepatitis C that is being developed in collaboration with Janssen Pharmaceuticals. Currently, hepatitis C virus(HCV) infection is considered a serious health-care problem all over the world. A good number of direct-acting ant...

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Blob Chronic Hepatitis (Chc), Viral Polymerase Nucleotide...

Created: 2019-10-12 11:22:31

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Sofosbuvir is a viral polymerase nucleotide inhibitor that was approved in December2013 by the United States Food and Drug Administration (FDA), and in January 2014by the European Medicines Agency for the treatment of HCV infection [1]. The WHOGuidelines for the screening, care and treatment of persons with hepatitis C infectionrecommend sofosbuvir in combination with ribavirin in genotypes 1, 2, 3 and 4 HCVinfection, either with or without pegylated interferon (depending on the HCV genotype)...

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Blob Bempedoic Acid a Small Molecule Drug Process and Syn...

Created: 2019-07-23 07:04:13

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Low Density Lipoprotein Cholesterol AbstractBempedoic acid (ETC-1002), a small molecule drug, promotes low density lipoprotein (LDL) receptor mediated clearanceof LDL-cholesterol (LDL-C) by inhibition of adenosine triphosphate citrate lyase (ACL), a mechanism complementary to thoseof existing lipid-modifying therapies. Bempedoic acid is a pro-drug activated specifically within the liver where it inhibits ACL,a regulatory checkpoint within the cholesterol biosynthesis pathway. By inhibiti...

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Blob Crystallization and Polymorphism-Scalable Process fo...

Created: 2018-12-04 11:45:47

Credits: User Drkrishnasarmapathy

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Crystallization and Polymorphism-Scalable Process for Celecoxib and It’s Polymorph From-3

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Blob Citation: Krishnasarma P, MS Chakravarthy. Crystalli...

Created: 2018-12-04 11:43:44

Credits: User Drkrishnasarmapathy

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Citation: Krishnasarma P, MS Chakravarthy. Crystallization and Polymorphism-Scalable Process for Celecoxib and It’s Polymorph From-3(Non- Steroidal Anti-Inflammatory Drug (NSAID). LOJ Med Sci 2(2)-2018. LOJMS.MS.ID.000134. 125Review ArticleCrystallization and Polymorphism-Scalable Process forCelecoxib and It’s Polymorph From-3 (Non- SteroidalAnti-Inflammatory Drug (NSAID) 

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Blob Cefpodoxime Proxetil and its By-Products: A Comparat...

Created: 2018-08-31 07:40:48

Credits: User Drkrishnasarmapathy

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Cefpodoxime Proxetil and its By-Products: A Comparative Study as Per EP-7 Krishnasarma pathy*LOJ Med Sci 

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Blob Biomedical Journal of Scientific & Technical Research.

Created: 2018-08-31 06:24:53

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Considerations for Successful Scale-Up to Tox Batches and Phase-Api (Bulk Drug substance)[*]       Krishnasarma pathy* DOI : 10.26717/BJSTR.2018.08.001662Biomedical Journal of Scientific & Technical Research.

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