File Entry: GLIBENCLAMIDE Complexes ( Complexes of Mg,Cr,Ni,Zn and Cd salts )Synthesis and characterization
Created: 2012-07-24 11:33:50
Last updated: 2012-07-24 11:33:51
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| Title | GLIBENCLAMIDE Complexes ( Complexes of Mg,Cr,Ni,Zn and Cd salts )Synthesis and characterization |
| File name | 39243027-DR-KRISHNASARMA-GLIBENCLAMIDE.pdf |
| File size | 660609 |
| SHA1 | d6cae7b03ea9bc1ab1b0d88674c7dcd9d0331bd5 |
| Content type | Adobe PDF |
Description
The N-acetyl derivative of β-phenethylamine is reacted with chlorosulfonic acid to form the para sulfonyl chloride derivative. This is then subjected to ammonolysis, followed by base-catalyzed removal of the acetamide. This is then acylated with 2-methoxy-5-chlorobenzoic acid chloride to give the amide intermediate. This is then reacted with cyclohexyl isocyanate to yield the sulfonylurea glibenclamide
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