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Created: 19/11/09 @ 18:18:52 | Last updated: 02/09/11 @ 11:44:57
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow searches for genes which reside in a QTL (Quantitative Trait Loci) region in the mouse, Mus musculus. The workflow requires an input of: a chromosome name or number; a QTL start base pair position; QTL end base pair position. Data is then extracted from BioMart to annotate each of the genes found in this region. The Entrez and UniProt identifiers are then sent to KEGG to obtain KEGG gene identifiers. The KEGG gene identifiers are then used to searcg for pathways in the KEGG path...
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Created: 03/10/07 @ 18:35:55 | Last updated: 26/11/09 @ 17:34:24 License: Creative Commons Attribution-No Derivative Works 3.0 Unported License
This workflow takes in a CEL file and a normalisation method then returns a series of images/graphs which represent the same output obtained using the MADAT software package (MicroArray Data Analysis Tool) [http://www.bioinf.manchester.ac.uk/MADAT/index.html]. Also returned by this workflow are a list of the top differentialy expressed genes (size dependant on the number specified as input - geneNumber), which are then used to find the candidate pathways which may be influencing the observed ...
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Created: 04/12/09 @ 16:04:38 | Last updated: 30/11/10 @ 12:18:53
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License: Creative Commons Attribution 3.0 Unported License
This workflow takes in Entrez gene ids then adds the string "ncbi-geneid:" to the start of each gene id. These gene ids are then cross-referenced to KEGG gene ids. Each KEGG gene id is then sent to the KEGG pathway database and its relevant pathways returned.
Rating: 4.8 / 5 (4 ratings) | Versions: 5 | Reviews: 0 | Comments: 2 | Citations: 0 Viewed: 1162 times | Downloaded: 463 times Tags (9): |
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Created: 24/11/09 @ 17:14:43 | Last updated: 03/12/09 @ 15:28:49 License: Creative Commons Attribution-No Derivative Works 3.0 Unported License
This workflow takes in two lists of KEGG pathway ids. These are designed to come from pathways found from genes in a QTL (Quantitative Trait Loci) region, and from pathways found from genes differentially expressed in a microarray study. By identifying the intersecting pathways from both studies, a more informative picture is obtained of the candidate processes involved in the expression of a phenotype.
Example input for this workflow is given below (as newline separated values).
qt...
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Created: 03/10/07 @ 18:36:05 | Last updated: 03/12/09 @ 16:20:33 License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow takes in probesets from and AffyMetrix micorarray experiment and returns: the genes ; gene start and end positions; chromosome where genes reside; ensembl trasncripts; SwissProt ids; affy probeset identifiers for chips Mouse430_2 and Mouse430a_2.
Example ids from the Mouse430_2 affymetrix array are as follows (newline separated):
1447227_at
1440624_at
1436240_at
1454904_at
1435665_at
1418148_at
1429831_at
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Created: 08/02/08 @ 14:17:23 | Last updated: 13/02/09 @ 11:29:52
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow takes in a CEL file and a normalisation method then returns a series of images/graphs which represent the same output obtained using the MADAT software package (MicroArray Data Analysis Tool) http://www.bioinf.manchester.ac.uk/MADAT/index.html. Also retruned by this workflow are a list of the top differentialy expressed genes (size dependant on the number specified as input - geneNumber), which are then used to find the candidate pathways which may be influencing the observed ch...
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Created: 08/02/08 @ 14:30:17 | Last updated: 03/12/09 @ 16:50:29
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow takes in probesets from and AffyMetrix Affy HG U133A micorarray experiment and returns: genes ; gene start and end positions; chromosome where genes reside; ensembl trasncripts; SwissProt ids. The final output of the workflow is a list of candidate pathways which are linked to the genes expressed in the microarray data.
Example input for this workflow is:
212283_at
221634_at
220399_at
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Created: 08/07/09 @ 16:28:34
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License: Creative Commons Attribution-No Derivative Works 3.0 Unported License
This workflow searches for genes which are found to be differentially expressed in a microarray study using Arabidopsis thaliana. The workflow requires an input of a list of differentially expressed AffyMetrix Probeset identifiers. Data is then extracted from BioMart to annotate each of the genes. The UniProt identifiers are then sent to KEGG to obtain KEGG gene identifiers. The KEGG gene identifiers are then used to searcg for pathways in the KEGG pathway database.
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Created: 10/08/09 @ 15:43:48
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow counts the number of articles in the pubmed database in which each term occurs, and identifies the total number of articles in the entire PubMed database. It also identified the total number of articles within pubmed so that a term enrichment score may be calculated.
The workflow also takes in a document containing abstracts that are related to a particular phenotype. Scientiifc terms are then extracted from this text and given a weighting according to the number of terms that ...
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Created: 15/11/10 @ 12:08:18 | Last updated: 16/11/10 @ 16:07:49
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow searches for genes which reside in a QTL (Quantitative Trait Loci) region in the mouse, Mus musculus. The workflow requires an input of: a chromosome name or number; a QTL start base pair position; QTL end base pair position. Data is then extracted from BioMart to annotate each of the genes found in this region. The Entrez and UniProt identifiers are then sent to KEGG to obtain KEGG gene identifiers. The KEGG gene identifiers are then used to searcg for pathways in the KEGG path...
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Created: 15/11/10 @ 12:30:21 | Last updated: 15/11/10 @ 12:30:59
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow takes in two lists of KEGG pathway ids. These are designed to come from pathways found from genes in a QTL (Quantitative Trait Loci) region, and from pathways found from genes differentially expressed in a microarray study. By identifying the intersecting pathways from both studies, a more informative picture is obtained of the candidate processes involved in the expression of a phenotype
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Created: 08/12/10 @ 11:35:18 | Last updated: 11/01/11 @ 12:05:41
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow calculates the cosine vector space between two sets of corpora. The workflow then removes any null values from the output. this is some extra text vbeing added
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Created: 08/12/10 @ 11:38:37 | Last updated: 11/01/11 @ 12:02:30
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow counts the number of articles in the pubmed database in which each term occurs, and identifies the total number of articles in the entire PubMed database. It also identified the total number of articles within pubmed so that a term enrichment score may be calculated. The workflow also takes in a document containing abstracts that are related to a particular phenotype. Scientiifc terms are then extracted from this text and given a weighting according to the number of terms that ...
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Created: 08/12/10 @ 11:47:10 | Last updated: 11/01/11 @ 12:00:16
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow takes in a list of KEGG pathway descriptions and searches the PubMed database for corresponding articles. Any matches to the pathways are then retrieved (abstracts only). These abstracts are then returned to the user.
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Created: 08/12/10 @ 11:50:01 | Last updated: 11/01/11 @ 11:58:09
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow takes in a document containg text and removes and non-ascii characters. The cleaned text is then sent to a service in dresden to extract all scientific terms. These terms represent a profile for the input document. Any null values are also removed.
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Created: 21/01/11 @ 16:56:47 | Last updated: 21/01/11 @ 16:58:50
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow searches for genes which reside in a QTL (Quantitative Trait Loci) region in Cow, Bos taurus. The workflow requires an input of: a chromosome name or number; a QTL start base pair position; QTL end base pair position. Data is then extracted from BioMart to annotate each of the genes found in this region. The Entrez and UniProt identifiers are then sent to KEGG to obtain KEGG gene identifiers. The KEGG gene identifiers are then used to searcg for pathways in the KEGG pathway data...
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Created: 10/02/11 @ 16:10:52 | Last updated: 18/02/11 @ 13:47:08
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow takes in a list of gene names and KEGG pathway descriptions, and searches the PubMed database for corresponding articles. Any matches to the genes are then retrieved (abstracts only). These abstracts are then used to calculate a cosine vector space between two sets of corpora (gene and phenotype, or pathway and phenotype). The workflow counts the number of articles in the pubmed database in which each term occurs, and identifies the total number of articles in the entire PubMe...
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Created: 17/03/11 @ 11:10:28 | Last updated: 30/08/11 @ 10:40:14
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow searches for genes which reside in a QTL (Quantitative Trait Loci) region in Human, Homo sapiens. The workflow requires an input of: a chromosome name or number; a QTL start base pair position; QTL end base pair position. Data is then extracted from BioMart to annotate each of the genes found in this region. The Entrez and UniProt identifiers are then sent to KEGG to obtain KEGG gene identifiers. The KEGG gene identifiers are then used to searcg for pathways in the KEGG pathway ...
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Created: 27/05/11 @ 11:06:11 | Last updated: 27/05/11 @ 11:06:52
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This workflow searches for genes which reside in a QTL (Quantitative Trait Loci) region in rice, Oryza sativa. The workflow requires an input of: a chromosome name or number; a QTL start base pair position; QTL end base pair position. Data is then extracted from BioMart to annotate each of the genes found in this region. The Entrez and UniGene identifiers are then sent to KEGG to obtain KEGG gene identifiers. The KEGG gene identifiers are then used to searcg for pathways in the KEGG pathway d...
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Created: 08/04/09 @ 13:14:54 | Last updated: 11/08/09 @ 14:50:01
It is increasingly common to combine Microarray and Quantitative Trait Loci data to aid the search for candidate genes responsible for phenotypic variation. Workflows provide a means of systematically processing large datasets, and represent a framework for the re-use and the explicit declaration of experimental methods. In this pack is a paper which describes the issues facing the manual analysis of microarray and QTL data for the discovery of candidate genes underlying complex phenotypes.&n...
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Created: 11/08/09 @ 14:44:16 | Last updated: 11/08/09 @ 14:52:12
This pack is for investigating links between the genotype of an organisms to possible pathways. This constitutes half of the pathway-driven approach, genotype to pathway, and pathway to phenotype.
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Created: 16/11/10 @ 16:20:43 | Last updated: 23/09/11 @ 10:55:08
This pack contains freely accessible data for scientific researchers to try and identify key genes linked to Bilateral Perisylvian Polymicrogyria. For those who want more information about this condition before they download the data, please see this link, which describes the condition and traits: http://omim.org/entry/300388?search=bilateral%20perisylvian%20polymicrogyria
The results conatined within this pack are the output from running a scientific workflow that identifies candidate genes...
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Created: 08/12/10 @ 11:55:03 | Last updated: 01/02/11 @ 11:33:11
This pack contains workflows to navigate from candidate Quantitative Trait genes and pathways to a given phenotype.
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Created: 16/02/11 @ 12:49:21 | Last updated: 16/02/11 @ 15:26:36
This pack contains the workflows and data relating to Trichuriasis induced colitis.
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Created: 08/04/09 @ 13:23:03
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This PDF is my personal copy of the NAR publication.
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Created: 08/04/09 @ 13:29:32
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This file contains the results of re-sequencing the Daxx gene
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Created: 11/08/09 @ 14:08:41 | Last updated: 11/08/09 @ 14:15:58
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This file contains all the abstracts for pathways found to be differentially expressed at day 7 post infection and intersect the Tir1 QTL region, from the African Trypanosomiasis project.
Each pathway is listed as ">> [Pathway Name]", together with a PubMed identifier, date, and abstract for each article. Each pathway has been restricted to 500 abstracts, and is given in the date range 31/12/2007 to 01/01/2009. Note, some pathways do not have any abstracts available due to th...
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Created: 07/12/10 @ 16:34:31 | Last updated: 07/12/10 @ 16:34:37
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This zip file contains the results of running a QTL workflow for Bilateral Perisylvian Polymicrogyria in human (homo sapiens). Provided are a list of candidate QTL genes (QTg) and their corresponding KEGG pathways. Each gene and pathway have been subsequently run through a series of text mining workflows to determine the significance of each may play in relation to Bilateral Perisylvian Polymicrogyria AND/OR Epilepsy. Further to this, I have also collected the SNPs (single nucleotide...
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Created: 16/02/11 @ 15:16:17 | Last updated: 16/02/11 @ 15:16:24
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License: Creative Commons Attribution-Share Alike 3.0 Unported License
This zip file contains the results of workflow runs for: identifying genes in each of the 7 QTL regions for Trichuris muris infection; identifying genes differentially expressed in mice challenged with Trichuris muris; and Text mining results (including cosine vector scores and Term Enrichment values).
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